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Myeloid leukaemias - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		41	52	43	58	48	53	48	42	385
Crude rate		6.0	7.7	6.4	8.7	7.2	7.9	7.0	6.1	7.1 (6.4‑7.9)
Standardized rate	Italy 2001	5.2	6.1	5.0	6.9	5.6	6.1	5.4	4.4	5.6 (5.0‑6.2)
Standardized rate	Europe	4.0	4.6	3.9	5.1	4.3	4.7	3.9	2.9	4.2 (3.7‑4.7)
Standardized rate	World	3.1	3.6	2.7	3.8	3.1	3.7	2.9	2.0	3.1 (2.7‑3.6)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		39	40	39	44	46	32	43	39	322
Crude rate		5.7	5.9	5.8	6.6	6.9	4.7	6.3	5.7	5.9 (5.3‑6.6)
Standardized rate	Italy 2001	4.2	4.7	4.5	4.9	4.8	3.3	4.2	3.9	4.3 (3.8‑4.8)
Standardized rate	Europe	2.5	3.3	3.1	3.4	3.1	2.1	2.6	2.4	2.8 (2.5‑3.2)
Standardized rate	World	1.6	2.3	2.1	2.3	2.0	1.4	1.6	1.5	1.9 (1.6‑2.2)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	80.8	77.0	90.0	71.0	85.7	54.1	77.8	88.6	76.8
Cito-histologically confirmed (%)	92.7	86.5	93.0	94.8	91.7	96.2	87.5	88.1	91.4
Death certificate only - DCO (%)	2.4	5.8	0.0	3.5	6.3	0.0	6.3	11.9	4.4

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	3.9	3.3	3.9	3.4	3.4	3.6
Mortality	2.5	2.2	2.2	2.8	1.8	2.2

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	178	91.8	174	91.1	352	91.4
Citological	0	0.0	0	0.0	0	0.0
Clinical	10	5.2	5	2.6	15	3.9
DCO	6	3.1	11	5.8	17	4.4

Table 6: More frequent morphologies

Morphology	N	%
Acute myeloid leukaemia, NOS (FAB or WHO type not specified) (see also M99303)	118	67.8
Chronic myeloid leukaemia, NOS	30	17.2
Chronic myelogenous leukaemia, BCRABL positive	7	4.0
Acute myelomonocytic leukaemia	5	2.9
Chronic myelomonocytic leukaemia, NOS	4	2.3
Acute leukaemia, NOS	2	1.1

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	1.1	0.0
10-14	1.1	0.0
15-19	0.0	0.0
20-24	2.0	0.0
25-29	0.6	0.0
30-34	3.2	0.5
35-39	1.4	0.5
40-44	3.5	0.5
45-49	5.3	1.8
50-54	5.4	1.8
55-59	5.8	4.8
60-64	5.8	3.7
65-69	5.7	7.3
70-74	15.9	16.5
75-79	15.9	13.9
80-84	30.3	34.6
85+	30.8	30.8

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	2.5	4.0
2000	3.3	4.6
2001	3.1	3.9
2002	3.4	5.1
2003	3.1	4.3
2004	2.1	4.7
2005	2.6	3.9
2006	2.4	2.9

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	5.1	5.0	5.8	5.2	4.7	6.0
2-5	4.8	4.2	4.1	4.7	5.7	5.6
5-10	4.3	4.6	4.7	4.2	4.1	5.2
10-15	2.9	2.6	2.5	3.0	3.0	3.1
15-20	1.5	1.4	1.2	1.5	1.5	1.6
>20	1.4	1.6	1.6	1.6	1.4	1.8

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	23.3 (17.9‑28.7)
North West	44.6 (42.0‑47.2)
North Est	44.5 (42.1‑46.8)
Centre	43.7 (39.9‑47.5)
South	46.6 (42.7‑50.3)
Italy	44.8 (43.3‑46.2)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	80.00	75.10	72.30	66.80	66.80
45-59	100.00	67.30	47.10	42.50	39.50	34.60
60-74	100.00	43.20	29.70	26.30	20.10	18.30
75+	100.00	20.20	16.30	10.80	9.30	8.70

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	44.3	41.1	44.8	39.9
2	35.5	30.2	37	27.8
3	31	27.4	31	24.2
4	22.3	24.6	30.3	21.8
5	19.8	22.5	27.2	21.8

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	5.8	7.1	5.8	9.2	6.5
Mortality	5.8	5.7	4.4	7	5.7

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	46.6	35.0
2	44.1	22.4
3	35.2	22.4
4	32.1	22.4
5	32.1	22.4