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Breast - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		1311	1423	1422	1359	1251	1465	1325	1258	10814
Crude rate		192.8	210.6	211.2	203.2	188.0	217.1	193.1	182.3	199.7 (196.0‑203.5)
Standardized rate	Italy 2001	161.2	173.6	174.0	167.9	153.4	177.7	160.1	149.2	164.5 (161.4‑167.7)
Standardized rate	Europe	129.0	140.3	139.3	136.8	123.6	144.4	130.3	118.7	132.8 (130.1‑135.5)
Standardized rate	World	95.0	102.3	102.3	100.9	90.9	106.4	95.7	86.9	97.5 (95.5‑99.7)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		435	408	421	392	388	357	377	361	3139
Crude rate		64.0	60.4	62.5	58.6	58.3	52.9	54.9	52.3	58.0 (56.0‑60.0)
Standardized rate	Italy 2001	48.9	45.8	47.3	42.9	43.0	39.3	40.6	37.4	43.1 (41.6‑44.7)
Standardized rate	Europe	34.3	31.8	33.7	29.7	30.7	27.6	28.2	24.7	30.1 (28.9‑31.3)
Standardized rate	World	23.4	21.7	23.0	20.1	21.2	19.0	19.2	16.5	20.5 (19.7‑21.4)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	30.3	26.4	27.2	25.6	28.0	22.1	25.4	25.1	26.2
Cito-histologically confirmed (%)	94.6	96.6	96.6	95.9	97.4	97.0	97.4	96.6	96.5
Death certificate only - DCO (%)	1.1	1.1	0.9	1.3	0.7	1.0	0.8	1.4	1.0

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	129.2	117.9	123.6	109.0	86.8	113.4
Mortality	27.8	26.4	25.1	22.2	24.1	24.7

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	5159	93.5	5020	94.7	10179	94.1
Citological	131	2.4	126	2.4	257	2.4
Clinical	165	3.0	96	1.8	261	2.4
DCO	60	1.1	51	1.0	111	1.0

Table 6: More frequent morphologies

Morphology	N	%
Infiltrating duct carcinoma, NOS (C50._)	3747	72.8
Lobular carcinoma, NOS (C50._)	619	12.0
Infiltrating duct and lobular carcinoma (C50._)	200	3.9
Carcinoma, NOS	173	3.4
Mucinous adenocarcinoma	73	1.4
Adenocarcinoma, NOS	53	1.0

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	0.0	0.0
20-24	1.0	0.0
25-29	9.0	0.6
30-34	27.3	1.4
35-39	66.2	5.4
40-44	162.3	14.5
45-49	247.5	32.7
50-54	258.9	40.2
55-59	303.6	50.4
60-64	336.2	73.7
65-69	364.1	93.8
70-74	343.3	104.2
75-79	408.3	137.4
80-84	368.9	181.9
85+	338.5	296.8

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	34.3	129.0
2000	31.8	140.3
2001	33.7	139.3
2002	29.7	136.8
2003	30.7	123.6
2004	27.6	144.4
2005	28.2	130.3
2006	24.7	118.7

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	289.7	194.6	278.3	314.6	350.5	385.2
2-5	384.5	246.9	373.0	421.3	468.6	499.1
5-10	472.8	289.7	448.5	507.9	589.2	671.8
10-15	309.6	184.7	297.0	350.5	398.1	450.2
15-20	194.6	114.3	189.7	216.1	242.5	288.2
>20	218.0	120.8	208.2	241.8	282.0	322.1

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	88.3 (87.0‑89.5)
North West	86.5 (85.8‑87.2)
North Est	85.1 (84.5‑85.7)
Centre	85.8 (84.8‑86.8)
South	81.4 (80.3‑82.5)
Italy	85.1 (84.7‑85.5)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	99.50	98.10	96.20	93.40	91.00
45-59	100.00	98.90	97.50	95.50	93.60	92.10
60-74	100.00	97.60	94.90	92.60	90.90	89.70
75+	100.00	94.70	91.00	88.90	86.90	85.30

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	97.5	96.7	98	97.7
2	94.7	94.3	95.5	95.5
3	92.5	91.6	94.4	92.9
4	90.2	89.5	91.9	91.8
5	88.9	87.8	90.2	90.3

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	199.1	188.1	203.7	170.6	178.8
Mortality	55.4	51.2	51.4	51.5	51.2

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	97.6	97.3
2	95.4	93.8
3	92.6	92.2
4	90.7	90.0
5	89.5	88.5