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Skin melanoma - Ladies

Rates per 100,000 inhabitants

Table 1: Incidence: frequencies, crude and standardized rates per year

Incidence		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		99	110	123	134	87	98	77	111	839
Crude rate		14.6	16.3	18.3	20.0	13.1	14.5	11.2	16.1	15.5 (14.5‑16.6)
Standardized rate	Italy 2001	13.0	14.7	16.9	17.7	11.4	12.4	9.6	14.0	13.7 (12.8‑14.7)
Standardized rate	Europe	11.2	12.5	15.1	15.0	9.7	10.6	7.9	11.7	11.7 (10.9‑12.6)
Standardized rate	World	8.7	10.0	12.6	11.8	7.8	8.5	6.2	9.2	9.3 (8.6‑10.1)

Table 2: Mortality: frequencies, crude and standardized rates per year

Mortality		1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Count		17	24	22	19	23	18	20	14	157
Crude rate		2.5	3.6	3.3	2.8	3.5	2.7	2.9	2.0	2.9 (2.5‑3.4)
Standardized rate	Italy 2001	2.0	2.6	2.6	2.2	2.5	2.2	2.3	1.7	2.2 (1.9‑2.6)
Standardized rate	Europe	1.5	1.7	1.9	1.6	1.7	1.7	1.7	1.3	1.6 (1.3‑1.9)
Standardized rate	World	1.1	1.1	1.4	1.1	1.2	1.3	1.2	0.9	1.1 (0.9‑1.4)

Table 3: Register quality indicators per year

Indicator	1999	2000	2001	2002	2003	2004	2005	2006	1999‑2006
Mortality/Incidence ratio (%)	15.4	17.7	15.4	12.4	21.9	17.7	24.0	12.1	16.1
Cito-histologically confirmed (%)	100.0	100.0	100.0	100.0	100.0	100.0	100.0	100.0	100.0
Death certificate only - DCO (%)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Table 4: Comparison of Italian Registries mean prevalence by macro-areas

Graf 04

_	Milan	North West	North East	Centre	South	Italy
Incidence	10.0	12.4	12.0	10.9	6.6	10.8
Mortality	1.6	1.4	1.7	1.6	1.3	1.6

Table 5: Basis of diagnosis per period

_	1999‑2002	%	2003‑2006	%	1999‑2006	%
Histological	465	99.8	373	100.0	838	99.9
Citological	1	0.2	0	0.0	1	0.1
Clinical	0	0.0	0	0.0	0	0.0
DCO	0	0.0	0	0.0	0	0.0

Table 6: More frequent morphologies

Morphology	N	%
Superficial spreading melanoma (C44._)	166	44.5
Epithelioid cell melanoma	100	26.8
Malignant melanoma, NOS (except juvenile melanoma M87700)	43	11.5
Lentigo maligna melanoma (C44._)	19	5.1
Nodular melanoma (C44._)	15	4.0
Mixed epithelioid and spindle cell melanoma	13	3.5

Table 7: Age distribution of rates

Graf 07

Age groups	Incidence	Mortality
0	0.0	0.0
1-4	0.0	0.0
5-9	0.0	0.0
10-14	0.0	0.0
15-19	2.4	0.0
20-24	4.9	0.0
25-29	5.8	0.0
30-34	8.8	0.0
35-39	12.2	2.3
40-44	18.5	2.5
45-49	15.2	1.2
50-54	12.6	4.2
55-59	18.0	2.7
60-64	18.8	3.1
65-69	20.8	2.6
70-74	20.5	3.4
75-79	19.9	8.0
80-84	28.6	6.1
85+	17.9	14.9

Table 8: Temporal trends of rates

Graf 08

Year	Mortality	Incidence
1999	1.5	11.2
2000	1.7	12.5
2001	1.9	15.1
2002	1.6	15.0
2003	1.7	9.7
2004	1.7	10.6
2005	1.7	7.9
2006	1.3	11.7

Table 10: Comparison of Italian Registries mean prevalence by macro-areas

Graf 10

Years since diagnosis	Italy	South	Centre	North East	North West	Milan
0-2	28.0	13.4	26.9	32.1	31.9	32.1
2-5	34.1	16.5	34.0	37.5	40.8	47.8
5-10	45.7	18.5	48.4	50.1	52.9	53.3
10-15	29.6	11.2	25.8	36.4	36.4	35.3
15-20	17.5	7.3	16.2	20.7	19.8	22.5
>20	26.0	10.1	25.1	30.1	31.1	32.1

Table 11: 5 years relative survival by macro-areas

Graf 11

Area	Relative survival (95% CI)
Milan	90.5 (87.4‑93.7)
North West	90.2 (88.4‑91.7)
North Est	88.9 (87.4‑90.3)
Centre	87.6 (85.0‑89.8)
South	82.3 (77.9‑85.9)
Italy	88.6 (87.6‑89.5)

Table 12: Relative survival by age since diagnosis

Age class	0	1	2	3	4	5
15-44	100.00	98.80	98.00	98.00	98.00	96.90
45-59	100.00	96.80	94.60	92.30	90.50	89.20
60-74	100.00	98.50	93.90	92.30	89.20	89.20
75+	100.00	91.50	86.00	84.00	81.50	75.20

Table 13: 5 years relative survival by biennium of incidence

Years since diagnosis	1999‑2000	2001‑2002	2003‑2004	2005‑2006
1	95.9	97.3	98.8	95.5
2	90.2	96	96	93
3	88.3	94.9	95	92.1
4	86	93.7	93.7	88.5
5	84.7	92.2	92.6	87

Table 14: Rates distribution by deprivation index

‑	1	2	3	4	5
Incidence	18.7	14.7	10.9	13.1	9.2
Mortality	2.7	3.1	2.5	2.3	2.7

Table 15: Relative survival by deprivation index

Years since diagnosis	Most deprived	Most affluent
0	100.0	100.0
1	94.5	99.2
2	88.6	95.8
3	88.6	95.0
4	87.3	90.9
5	83.9	89.0